We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
EPIGENETIC MODULATION IN THE PRODUCTION OF FUNGAL ANTIMICROBIALS: A SYSTEMATIC REVIEW.
- Authors
Araújo, Tiago da Silva; de Souza, Emerson Pequeno; da Silva, Sarah Cavalcanti; Ramos, Diego Gomes; Converti, Attilio; Viana Marques, Daniela de Araújo; Silveira Filho, Vladimir da Mota; Lima Duarte, Carolina de Albuquerque
- Abstract
Fungal bioactive compounds can be used by pharmaceutical, agricultural or food industries, and their discovery and identification is closely linked to the methodologies applied in the process. The current knowledge of filamentous fungi genome mining has shown that many genes encoding biosynthetic pathways are silenced, thus limiting their ability to produce metabolites under commonly used laboratory conditions. These biosynthetic pathways may produce substances with antimicrobial potential, but more specific conditions are needed for their activation. This review article shows that the treatment of these fungi with epigenetic modulators such as DNA methyltransferase (DNMT) inhibitors and/or histone deacetylase (HDAC) inhibitors is an approach capable of triggering activation of biosynthetic pathways previously silenced epigenetically. Due to the extensive metabolic diversity of filamentous fungi, epigenetic chromatin modulation appears to be an innovative methodology that can lead to great discoveries in the field of bioprospecting of compounds, not only antimicrobials, as well as to the proven possibility of maximizing the production of known compounds.
- Subjects
EPIGENETICS; FILAMENTOUS fungi; ANTI-infective agents; DNA methyltransferases; GENE expression; BIOACTIVE compounds; HISTONE deacetylase; META-analysis
- Publication
Revista Foco (Interdisciplinary Studies Journal), 2023, Vol 16, Issue 10, p1
- ISSN
1981-223X
- Publication type
Article
- DOI
10.54751/revistafoco.v16n10-161