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- Title
Ophthalmic artery peak systolic velocity ratio distinguishes pre‐eclampsia from chronic and gestational hypertension: A prospective cohort study.
- Authors
Lau, Katherine G. Y.; Wright, Allan; Kountouris, Emmanouil; Nicolaides, Kypros H.; Kametas, Nikos A.
- Abstract
Objective: To examine whether the ophthalmic artery peak systolic velocity ratio (OA PSV‐ratio) is higher in women with pre‐eclampsia compared with gestational hypertension (GH) and chronic hypertension (CH), after controlling for confounding variables. Design: Prospective cohort. Setting: Specialist hypertension clinic in a tertiary referral centre. Population: Singleton pregnancies presenting between 32+0 and 36+6 weeks of gestation with pre‐eclampsia (n = 50), GH (n = 54) and CH (n = 56). Methods: Paired measurements of maternal mean arterial pressure (MAP) and OA PSV‐ratio were performed by trained sonographers. Multiple linear regression was fitted to the OA PSV‐ratio, including maternal characteristics and medical history, GH, pre‐eclampsia and MAP and use of antihypertensive medication. Main Outcome Measure: Whether pre‐eclampsia is independently associated with higher OA PSV‐ratio. Results: MAP was significantly higher in both GH (p = 0.0015) and pre‐eclampsia (p = 0.008) than in CH pregnancies. There was no significant difference between pre‐eclampsia and GH (0.670). The OA PSV‐ratio was significantly higher in pre‐eclampsia than CH (p = 0.0008) and GH (p = 0.015). There was no significant difference between the OA PSV‐ratio in CH and GH (p = 0.352). Multiple linear regression modelling showed that the OA PSV‐ratio was influenced by maternal weight (p = 0.005), maternal age (p = 0.014), antihypertensive medications (p = 0.007) and MAP (p < 0.0001). After controlling for these variables, the OA PSV‐ratio was still significantly higher in those with pre‐eclampsia (p = 0.0002). Conclusions: The OA PSV‐ratio is influenced by maternal weight, age, antihypertensive medications and MAP. Pre‐eclampsia is an independent predictor of OA PSV‐ratio, which therefore may be a useful point‐of‐care test when assessing women presenting with hypertension. Ophthalmic artery peak systolic velocity ratio is higher in pre‐eclampsia compared with gestational or chronic hypertension. Linked article: This article is commented on by Markus Gonser et al., pp. 1394‐1395 in this issue. To view this minicommentary visit https://doi.org/10.1111/1471-0528.17062. This article includes Author Insights, a video abstract available at: https://vimeo.com/bjog/authorinsights17061. This article has a Video Abstract presented by Katherine Lau.
- Subjects
OPHTHALMIC artery; PREECLAMPSIA; ANTIHYPERTENSIVE agents; HYPERTENSION; HYPERTENSION in women
- Publication
BJOG: An International Journal of Obstetrics & Gynaecology, 2022, Vol 129, Issue 8, p1386
- ISSN
1470-0328
- Publication type
Article
- DOI
10.1111/1471-0528.17061