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- Title
Unraveling virus relationships by structure-based phylogenetic classification.
- Authors
Ng, Weng M; Stelfox, Alice J; Bowden, Thomas A
- Abstract
Delineation of the intricacies of protein function from macromolecular structure constitutes a continual obstacle in the study of cell and pathogen biology. Structure-based phylogenetic analysis has emerged as a powerful tool for addressing this challenge, allowing the detection and quantification of conserved architectural properties between proteins, including those with low or no detectable sequence homology. With a focus on viral protein structure, we highlight how a number of investigations have utilized this powerful method to infer common functionality and ancestry.
- Subjects
PROTEIN structure; MACROMOLECULES; PHYLOGENETIC models; PROTEINS; VIRUSES; COMPARATIVE genetics
- Publication
Virus Evolution, 2020, Vol 6, Issue 1, p1
- ISSN
2057-1577
- Publication type
Article
- DOI
10.1093/ve/veaa003