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- Title
Exacerbation of protracted-relapsing experimental allergic encephalomyelitis in DA rats by gluten-free diet.
- Authors
Di Marco, Roberto; Mangano, Katia; Quattrocchi, Cinzia; Amato, Filiberto; Nicoletti, Ferdinando; Buschard, Karsten
- Abstract
Di Marco R, Mangano K, Quattrocchi C, Amato F, Nicoletti F, Buschard K. Exacerbation of protracted-relapsing experimental allergic encephalomyelitis in DA rats by gluten-free diet. APMIS 2004;112:651–5.The observation of neurological dysfunctions resembling multiple sclerosis (MS) seen clinically and/or by MRI in patients with celiac disease has focused attention on the possibility that cryptic gluten sensitivity may be involved in the pathogenesis of MS. Here we study the effects of a gluten-free diet on the course of protracted-relapsing EAE in DA rats, serving as a preclinical model of human MS. The data show not only that this nutritional approach failed to ameliorate development of the disease but rather that it exacerbated the course.
- Subjects
ALLERGIC encephalomyelitis; ENCEPHALOMYELITIS; LABORATORY rats; GLUTEN-free diet; MULTIPLE sclerosis
- Publication
APMIS, 2004, Vol 112, Issue 10, p651
- ISSN
0903-4641
- Publication type
Article
- DOI
10.1111/j.1600-0463.2004.apm1121003.x