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- Title
Depletion of Langerhans cells in cervical HPV infection is associated with replication of the virus.
- Authors
LEHTINEN, MATTI; RANTALA, IMMO; TOIVONEN, ANNE; LUOTO, HARRI; AINE, RISTO; LAUSLAHTI, KALEVI; YLÄ-OUTINEN, ARI; ROMPPANEN, URSULA; PAAVONEN, JORMA
- Abstract
We studied the quantity of Langerhans cells in 36 patients with cervical human papillomavirus (HPV) infection. Significantly fewer Langerhans cells (p<0.05) were found in patients with compared to those without DNA tetraploidy. Similarly, patients positive for HPV 16/18 DNA by in situ hybridization or antipeptide IgA antibodies to HPV 18 tended to have fewer Langerhans cells than those negative for HPV 16/18 DNA or IgA antibodies. Our results suggest that depletion of Langerhans cells is associated with productive HPV 16/18 infection in the cervical epithelium.
- Publication
APMIS, 1993, Vol 101, Issue 7-12, p833
- ISSN
0903-4641
- Publication type
Article
- DOI
10.1111/j.1699-0463.1993.tb00188.x