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- Title
末梢血酮与尿酮在糖尿病酮症诊治中的临床应用价值比较.
- Authors
江华; 刘敏; 王聪; 荆丹清; 白桦; 贾喆; 尹士男
- Abstract
Objective: To compare the clinical significance of capillary blood β-hydroxybutyrate and urine ketone in diagnosing and monitoring DK. Methods: 161 cases of hospitalized diabetes patients with a capillary glucose level>13.9 mmol/L in endocrinology department of our hospital were collected from October 2013 to December 2014. They included 29 patients with DK and 132 patients without DK according to urine ketone. We analyzed the correlation between blood ketone and urine ketone, established the capillary blood β-hydroxybutyrate threshold for diagnosing DK by using receiver operating characteristic (ROC) and compare their advantages and disadvantages in monitoring the response to treatment. Results: Capillary blood ketone had a positive correlation with urine ketone, and blood ketone increased with the increase of urine ketone (r=0.493, P<0.001). But they both had no significant correlation with blood glucose(P=0.358, P=0.133). When urine ketone was used as the reference test for diagnosis of DK, area under the ROC curves was 0.843 (CI, 0.746-0.939), and the optimal value of capillary blood β-hydroxybutyrate was 0.25 mmol/L. In the course of treatment and monitoring of DK, blood ketone peaked faster and turned to be negative earlier than urine ketone. Conclusions: There is a good correlation between blood ketone and urine ketone. Capillary blood ketone testing has good sensitivity, timeliness and accuracy. It is helpful to rapid and accurate diagnosis of DK and to reduce the occurrence and development of severe diabetic ketoacidosis (DKA). It could also reduce emergency department assessment, hospitalization and time to recovery from DK or DKA, as well as potentially lower healthcare expenditure. Blood ketone test has instructive significance in therapy and it is worthy of clinical application.
- Publication
Progress in Modern Biomedicine, 2016, Vol 16, Issue 15, p2872
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2016.15.017