We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
In Vitro study of Effect of MI on the Insulin-resistant HepG2 Cell Model.
- Authors
GAO Li-he; SONG Yang; LIU Cui-ping; FU Min; WANG Peng
- Abstract
Objective: To explore effect of myo-inositol(MI) on improving glucose consumption of insulin-resistant HepG2(IR-HepG2) cell model. Methods: IR-HepG2 cell model was established by high glucose and insulin stimulation. Successful authentication of model was determined by glucose oxidase method(GOD-POD). Effect of high glucose, MI on activity of HepG2 cells was detected by CCK-8 assay. Glucose consumption of normal HepG2 cell and IR-HepG2 cell were determined by GOD-POD. Results:MI treatment groups had no valid influence on HepG2 cell, while they could increase glucose consumption of IR-HepG2 cell. GOD-POD analysis found that compared with model control group, consumption of D-glucose was significantly higher in MI treatment groups(P<0.01). Conclusions: The MI could significantly promote the glucose consumption of the insulin-resistant HepG2 cell to improve the insulin resistance.
- Subjects
INOSITOL; INSULIN resistance; TYPE 2 diabetes
- Publication
Progress in Modern Biomedicine, 2016, Vol 16, Issue 12, p2245
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2016.12.011