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- Title
Autism Spectrum Disorder is Related to Increasing Intestinal Prevotella That Can Be Regulated by Vitamin A.
- Authors
Xiaoou Xu; Yun Zhang; Xiaojuan Zhang
- Abstract
Background: Increasing studies suggest that the microbiome-gut-brain axis plays a fundamental role in developing autism spectrum disorder (ASD). Objectives: We aimed to explore biomarkers from gut bacteria in ASD and the dietary vitamin A (VitA) relationship with intestinal bacteria of autistic children and provide a theoretical basis for dietary regulation of ASD. Methods: Ten autistic children aged 2 to 6 from special training facilities were enrolled from 2017 to 2018. At the same time, 10 healthy children aged 2 to 6 from a kindergarten were collected as a control. All participants were from Chongqing, China. The 16sRNA amplicon sequencing was used to analyze children's intestinal bacteria. The serum retinol level was detected by highperformance liquid chromatography (HPLC), and children's dietary intake was analyzed using three-day 24-hour dietary recalls. Results: There were significant differences in alpha diversitybetweenthe groups. Also, a higher relativeabundanceof Prevotellaceae, Prevotella 9, and Roseburia was observed among ASD children. We also found decreases in 9 bacteria (Enterobacteriales, Gammaproteobacteria, Enterobacteriaceae, Clostridiaceae 1, Clostridium sensu stricto 1, Escherichia-Shigella, Bacteroides fragilis, Escherichia coli, and Clostridium neonatale). Dietary VitA intake and serum retinol concentration were lower in the ASD group than in the control group. Meanwhile, serum VitA had a significantly negative correlation with the abundance of intestinal Prevotella 9. Conclusions: Our study helps identify some bacterial biomarkers for ASD, as in previous reports. Meanwhile, the study suggests that dietary VitA may be involved in the clinical symptoms of ASD by regulating the intestinal bacteria Prevotella. It may provide a new way to treat ASD in the future. Further studies are needed to identify the results by expanding the sample size and developing animal experiments.
- Subjects
CHONGQING (China); AUTISM spectrum disorders; PREVOTELLA; SHIGELLOSIS; AUTISTIC children; GAMMAPROTEOBACTERIA; INTESTINES
- Publication
Iranian Journal of Psychiatry & Behavioral Sciences / Progress in Psychiatry & Behavioral Sciences, 2023, Vol 17, Issue 2, p1
- ISSN
1735-8639
- Publication type
Article
- DOI
10.5812/ijpbs-126508