We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Formaldehyde-induced depression of skin reactivity to 5-chloro-2-methyl-4-isothiazolin-3-one in the guinea pig.
- Authors
Bruze, Magnus; Gruvberger, Birgitta
- Abstract
The guinea pig maximization test (GPMT) has recently been used for sensitization studies with formaldehyde at two different laboratories. When using a toxic concentration of formaldehyde for intracutaneous induction, a decrease in the sensitization was recorded. Inflammatory processes in the guinea pig can both depress and enhance skin reactivity, so the purpose of this study was to investigate whether a toxic dose of formaldehyde would depress the skin reactivity to an unrelated contact sensitizer using the GPMT for sensitization.
- Subjects
SKIN tests; GUINEA pigs as laboratory animals; FORMALDEHYDE; POISONS; SKIN; DISINFECTION &; disinfectants
- Publication
Contact Dermatitis (01051873), 1988, Vol 19, Issue 3, p231
- ISSN
0105-1873
- Publication type
Article
- DOI
10.1111/j.1600-0536.1988.tb02913.x