We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Synthesis, Spectral Characterization and biological activity of N-Substituted Derivatives of Tetrahydrofuran-2-ylmethylamine.
- Authors
Aziz-ur-Rehman; Rasool, S.; Abbasi, M. A.; Khan, K. M.; Ahmad, I.; Afzal, S.
- Abstract
Tetrahydrofuran-2-ylmethylamine (1) was subjected to condensation reaction with 4-chlorobenzenesulfonyl chloride (2) in a mild basic medium to synthesize N-(tetrahydrofuran-2-ylmethyl)-4-chlorobenzenesulfonamide (3). A series of N-substituted derivatives, 5a-f, were synthesized by condensing alkyl/aralkyl halides, 4a-f, with 3 under polar aprotic conditions using sodium hydride activator. The spectral characterization of all the molecules included IR, 1H-NMR and EI-MS data. The biological activity evaluation rendered 5c as moderate inhibitor of all the bacterial strains.
- Subjects
TETRAHYDROFURAN derivatives; SULFONAMIDES; ANTIBACTERIAL agents
- Publication
Pakistan Journal of Chemistry, 2014, Vol 4, Issue 2, p62
- ISSN
2220-2625
- Publication type
Article
- DOI
10.15228/2014.v04.i02.p02