We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Functional polymorphisms in the promoter region of MMP-2 and MMP-9 and susceptibility to obstructive sleep apnea.
- Authors
Cao, Chao; Wu, Bin; Wu, Yanping; Yu, Yiming; Ma, Hongying; Sun, Shifang; Zhang, Qiaoli; Ding, Qunli; Chen, Li; Deng, Zaichun
- Abstract
Genetic susceptibility to obstructive sleep apnea (OSA) has been a research focus in the scientific community in the past few years. In this study, we recruited 375 subjects to investigate whether functional polymorphisms in the promoter region of matrix metalloproteinase (MMP)-2 (-1306C/T) and MMP-9 (-1562C/T) increased susceptibility to OSA. Our study showed no significant association between MMP-2 -1306C/T polymorphism and risk of OSA (T vs. C: OR = 1.01, 95% CI = 0.67-1.52; P = 0.97). Compared with the MMP-9 -1562C allele, the -1562T allele was associated with increased risk of OSA (T vs. C: OR = 1.56, 95% CI = 1.02-2.39; P = 0.04). However, neither MMP-2 -1306C/T nor MMP-9 -1562C/T polymorphism was found to be associated with severity of the disease. Our study suggested that the MMP-2 -1306C/T polymorphism was not associated with OSA susceptibility, whereas the MMP-9 -1562T allele was associated with increased risk of OSA.
- Subjects
GENETIC polymorphisms; SLEEP apnea syndromes; MATRIX metalloproteinases; ENDOPEPTIDASES; CHEYNE-Stokes respiration
- Publication
Scientific Reports, 2015, p8966
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep08966