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- Title
Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth.
- Authors
Aki Yamashita; Kei Kawana; Kensuke Tomio; Ayumi Taguchi; Yosuke Isobe; Ryo Iwamoto; Koji Masuda; Hitomi Furuya; Takeshi Nagamatsu; Kazunori Nagasaka; Takahide Arimoto; Katsutoshi Oda; Osamu Wada-Hiraike; Takahiro Yamashita; Yuji Taketani; Kang, Jing X.; Shiro Kozuma; Hiroyuki Arai; Makoto Arita; Yutaka Osuga
- Abstract
Omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) have anti-inflammatory effects. Preterm birth is an important problem in modern obstetrics and one of the main causes is an inflammation. We here showed that abundance of omega-3 fatty acids reduced the incidence of preterm birth induced by LPS with fat-1 mice, capable of converting omega-6 to omega-3 fatty acids. We also indicated that the gene expression of IL-6 and IL-1b in uteruses and the number of cervical infiltrating macrophages were reduced in fat-1 mice. The analyses of lipid metabolomics showed the high level of 18-hydroxyeicosapentaenoate in fat-1 mice, which was derived from EPA and was metabolized to anti-inflammatory product named resolvin E3 (RvE3). We finally showed that the administration of RvE3 to LPS-exposed pregnant wild type mice lowered the incidence of preterm birth. Our data suggest that RvE3 could be a potential new therapeutic for the prevention of preterm birth.
- Subjects
UNSATURATED fatty acids; CHILDBIRTH; EICOSAPENTAENOIC acid; OBSTETRICS; OMEGA-3 fatty acids; PREMATURE infants; PREMATURE labor
- Publication
Scientific Reports, 2013, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep03113