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Synthesis of 1-[4-(m-tolyl)amino-6-quinazolinyl]-3-[<sup>14</sup>C]-methyl triazene: a radiolabeled probe for the combi-targeting concept.
- Published in:
- Journal of Labelled Compounds & Radiopharmaceuticals, 2003, v. 46, n. 8, p. 729
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- Publication type:
- Article
Design and Mechanism of Action of a New Prototype of Combi-Molecule "Programed" to Release Bioactive Species at a pH Range Akin to That of the Tumor Microenvironment.
- Published in:
- Pharmaceuticals (14248247), 2021, v. 14, n. 2, p. 160, doi. 10.3390/ph14020160
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- Publication type:
- Article
Positional Isomerization of A Non-Cleavable Combi-Molecule Dramatically Altered Tumor Cell Response Profile.
- Published in:
- Chemical Biology & Drug Design, 2015, v. 85, n. 2, p. 153, doi. 10.1111/cbdd.12402
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- Publication type:
- Article
Biological Effects of AL622, a Molecule Rationally Designed to Release an EGFR and a c-Src Kinase Inhibitor.
- Published in:
- Chemical Biology & Drug Design, 2012, v. 80, n. 6, p. 981, doi. 10.1111/cbdd.12043
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- Publication type:
- Article
Synthesis and Studies on Three-Compartment Flavone-Containing Combi-Molecules Designed to Target EGFR, DNA, and MEK.
- Published in:
- Chemical Biology & Drug Design, 2011, v. 77, n. 5, p. 309, doi. 10.1111/j.1747-0285.2011.01098.x
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- Publication type:
- Article
Rational Design of Multitargeted Tyrosine Kinase Inhibitors: A Novel Approach.
- Published in:
- Chemical Biology & Drug Design, 2009, v. 73, n. 4, p. 380, doi. 10.1111/j.1747-0285.2009.00786.x
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- Publication type:
- Article
Quantitative Analysis of the Potency of Equimolar Two-Drug Combinations and Combi-Molecules Involving Kinase Inhibitors In Vitro: The Concept of Balanced Targeting.
- Published in:
- International Journal of Molecular Sciences, 2021, v. 22, n. 17, p. 9569, doi. 10.3390/ijms22179569
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- Publication type:
- Article
Temporal Effects of Quercetin on Tight Junction Barrier Properties and Claudin Expression and Localization in MDCK II Cells.
- Published in:
- International Journal of Molecular Sciences, 2019, v. 20, n. 19, p. 4889, doi. 10.3390/ijms20194889
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- Publication type:
- Article
A type I combi-targeting approach for the design of molecules with enhanced potency against BRCA1/2 mutant- and O6-methylguanine-DNA methyltransferase (mgmt)- expressing tumour cells.
- Published in:
- 2017
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- Publication type:
- journal article
Isolation of hydrocarbon-degrading extremely halophilic archaea from an uncontaminated hypersaline pond (Camargue, France).
- Published in:
- Extremophiles, 2010, v. 14, n. 2, p. 225, doi. 10.1007/s00792-010-0301-z
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- Publication type:
- Article
Peanut allergen characterization and allergenicity throughout development.
- Published in:
- Frontiers in Allergy, 2024, p. 1, doi. 10.3389/falgy.2024.1395834
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- Publication type:
- Article
Peanut allergen characterization and allergenicity throughout development.
- Published in:
- Frontiers in Allergy, 2024, p. 1, doi. 10.3389/falgy.2024.1395834
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- Publication type:
- Article
Antiinflammatory and Proinflammatory Cytokines in Patients with Severe Sepsis.
- Published in:
- Journal of Infectious Diseases, 1995, v. 172, n. 4, p. 1171
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- Publication type:
- Article
Soluble Interleukin-6 Receptor in Patients with Severe Sepsis.
- Published in:
- Journal of Infectious Diseases, 1995, v. 172, n. 2, p. 607, doi. 10.1093/infdis/172.2.607
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- Publication type:
- Article
Local Synthesis of Tumor Necrosis Factor-α and Interleukin-l in the Peritoneal Cavity during Spontaneous Bacterial Peritonitis.
- Published in:
- Journal of Infectious Diseases, 1991, v. 164, n. 6, p. 1242
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- Publication type:
- Article
Synthesis of Water Soluble Bis-triazenoquinazolines: An Unusual Predicted Mode of Binding to the Epidermal Growth Factor Receptor Tyrosine Kinase.
- Published in:
- Chemical Biology & Drug Design, 2008, v. 71, n. 4, p. 374, doi. 10.1111/j.1747-0285.2008.00638.x
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- Publication type:
- Article
Subcellular distribution and mechanism of action of AL906, a novel and potent EGFR inhibitor rationally designed to be green fluorescent.
- Published in:
- Investigational New Drugs, 2021, v. 39, n. 1, p. 240, doi. 10.1007/s10637-020-00958-7
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- Publication type:
- Article
Modifiable Risk Factors for Delirium in Critically Ill Trauma Patients: A Multicenter Prospective Study.
- Published in:
- Journal of Intensive Care Medicine, 2019, v. 34, n. 4, p. 330, doi. 10.1177/0885066617698646
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- Publication type:
- Article
The Concept of Divergent Targeting through the Activation and Inhibition of Receptors as a Novel Chemotherapeutic Strategy: Signaling Responses to Strong DNA-Reactive Combinatorial Mimicries.
- Published in:
- Journal of Signal Transduction, 2012, p. 1, doi. 10.1155/2012/282050
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- Publication type:
- Article
Target Modulation by a Kinase Inhibitor Engineered to Induce a Tandem Blockade of the Epidermal Growth Factor Receptor (EGFR) and c-Src: The Concept of Type III Combi-Targeting.
- Published in:
- PLoS ONE, 2015, v. 10, n. 2, p. 1, doi. 10.1371/journal.pone.0117215
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- Publication type:
- Article
Pro-Oxidant Auranofin and Glutathione-Depleting Combination Unveils Synergistic Lethality in Glioblastoma Cells with Aberrant Epidermal Growth Factor Receptor Expression.
- Published in:
- Cancers, 2024, v. 16, n. 13, p. 2319, doi. 10.3390/cancers16132319
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- Publication type:
- Article
ZRX1, the first EGFR inhibitor-capecitabine based combi-molecule, requires carboxylesterase-mediated hydrolysis for optimal activity.
- Published in:
- Investigational New Drugs, 2013, v. 31, n. 6, p. 1409, doi. 10.1007/s10637-013-0008-y
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- Publication type:
- Article
Characterization of the potency of epidermal growth factor (EGFR)-DNA targeting combi-molecules containing a hydrolabile carbamate at the 3-position of the triazene chain.
- Published in:
- Investigational New Drugs, 2011, v. 29, n. 5, p. 833, doi. 10.1007/s10637-010-9431-5
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- Publication type:
- Article
Inhibition of EGFR phosphorylation in a panel of human breast cancer cells correlates with synergistic interactions between gefitinib and 5′-DFUR, the bioactive metabolite of Xeloda.
- Published in:
- Breast Cancer Research & Treatment, 2012, v. 133, n. 1, p. 217, doi. 10.1007/s10549-011-1756-z
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- Publication type:
- Article
Anticancer metallopharmaceutical agents based on mixed-ligand palladium(II) complexes with dithiocarbamates and tertiary organophosphine ligands.
- Published in:
- Applied Organometallic Chemistry, 2013, v. 27, n. 7, p. 387, doi. 10.1002/aoc.2991
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- Publication type:
- Article
Effects of Spilled Oil on Bacterial Communities of Mediterranean Coastal Anoxic Sediments Chronically Subjected to Oil Hydrocarbon Contamination.
- Published in:
- Microbial Ecology, 2007, v. 54, n. 4, p. 646, doi. 10.1007/s00248-007-9221-6
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- Publication type:
- Article
Molecular Profiling of Peanut under Raw, Roasting, and Autoclaving Conditions Using High-Resolution Magic Angle Spinning and Solution 1 H NMR Spectroscopy.
- Published in:
- Molecules, 2024, v. 29, n. 1, p. 162, doi. 10.3390/molecules29010162
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- Publication type:
- Article
Validation and comparison of CAM-ICU and ICDSC in mild and moderate traumatic brain injury patients.
- Published in:
- 2016
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- Publication type:
- research
Pentosan polysulfate-induced thrombocytopenia and thrombosis.
- Published in:
- American Journal of Hematology, 1994, v. 45, n. 3, p. 252, doi. 10.1002/ajh.2830450312
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- Publication type:
- Article
Multiple mechanisms of action of ZR2002 in human breast cancer cells: A novel combi-molecule designed to block signaling mediated by the ERB family of oncogenes and to damage genomic DNA.
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- International Journal of Cancer, 2004, v. 112, n. 3, p. 484, doi. 10.1002/ijc.20383
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- Publication type:
- Article
Dasatinib + Gefitinib, a non platinum-based combination with enhanced growth inhibitory, anti-migratory and anti-invasive potency against human ovarian cancer cells.
- Published in:
- Journal of Ovarian Research, 2017, v. 10, p. 1, doi. 10.1186/s13048-017-0319-2
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- Publication type:
- Article
Adrenal axis function does not appear to be associated with hemodynamic improvement in septic shock patients systematically receiving glucocorticoid therapy.
- Published in:
- 2006
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- Publication type:
- journal article
Weaning from mechanical ventilation with pressure support in patients failing a T-tube trial of spontaneous breathing.
- Published in:
- 2006
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- Publication type:
- journal article
Prognostic factors in acute respiratory distress syndrome: a retrospective multivariate analysis including prone positioning in management strategy.
- Published in:
- 2003
- By:
- Publication type:
- journal article
Use of electrospray ionization mass spectrometry for profiling of crude oil effects on the phospholipid molecular species of two marine bacteria.
- Published in:
- Rapid Communications in Mass Spectrometry: RCM, 2005, v. 19, n. 23, p. 3579, doi. 10.1002/rcm.2231
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- Publication type:
- Article
Dasatinib sensitises triple negative breast cancer cells to chemotherapy by targeting breast cancer stem cells.
- Published in:
- 2018
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- Publication type:
- journal article
'Combi-targeting' mitozolomide: Conferring novel signaling inhibitory properties to an abandoned DNA alkylating agent in the treatment of advanced prostate cancer.
- Published in:
- Prostate, 2012, v. 72, n. 12, p. 1273, doi. 10.1002/pros.22475
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- Publication type:
- Article
Inhibition of cell signaling by the combi-nitrosourea FD137 in the androgen independent DU145 prostate cancer cell line.
- Published in:
- Prostate, 2004, v. 59, n. 1, p. 13, doi. 10.1002/pros.10353
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- Publication type:
- Article
Differential responses of EGFR-/AGT-expressing cells to the "combi-triazene" SMA41.
- Published in:
- Cancer Chemotherapy & Pharmacology, 2003, v. 51, n. 1, p. 11, doi. 10.1007/s00280-002-0525-4
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- Publication type:
- Article
The combi-targeting concept: a novel 3,3-disubstituted nitrosourea with EGFR tyrosine kinase inhibitory properties.
- Published in:
- Cancer Chemotherapy & Pharmacology, 2003, v. 51, n. 1, p. 1, doi. 10.1007/s00280-002-0524-5
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- Publication type:
- Article
Radiomics in Glioblastoma: Current Status and Challenges Facing Clinical Implementation.
- Published in:
- Frontiers in Oncology, 2019, p. N.PAG, doi. 10.3389/fonc.2019.00374
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- Publication type:
- Article
Temozolomide Induced Hypermutation in Glioma: Evolutionary Mechanisms and Therapeutic Opportunities.
- Published in:
- Frontiers in Oncology, 2019, p. N.PAG, doi. 10.3389/fonc.2019.00041
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- Publication type:
- Article
Molecular Analysis of the Superior Efficacy of a Dual Epidermal Growth Factor Receptor (EGFR)-DNA-Targeting Combi-Molecule in Comparison with Its Putative Prodrugs 6-Mono-Alkylamino- and 6,6-Dialkylaminoquinazoline in a Human Osteosarcoma Xenograft Model.
- Published in:
- Cells (2073-4409), 2023, v. 12, n. 6, p. 914, doi. 10.3390/cells12060914
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- Publication type:
- Article
<sup>15</sup>N-, <sup>13</sup>C- and ¹H-NMR Spectroscopy Characterization and Growth Inhibitory Potency of a Combi-Molecule Synthesized by Acetylation of an Unstable Monoalkyltriazene.
- Published in:
- Molecules, 2017, v. 22, n. 7, p. 1183, doi. 10.3390/molecules22071183
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- Publication type:
- Article
Pilot study investigating the prognostic significance of thymidine phosphorylase expression in patients with metastatic breast cancer: a single institution retrospective analysis.
- Published in:
- OncoTargets & Therapy, 2015, v. 8, p. 911, doi. 10.2147/OTT.S71089
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- Publication type:
- Article
High Sensitivity and Specificity of Serum Procalcitonin Levels in Adults with Bacterial Meningitis.
- Published in:
- Clinical Infectious Diseases, 1999, v. 28, n. 6, p. 1313, doi. 10.1086/514793
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- Publication type:
- Article
High Levels of Tumor Necrosis Factor-α and Interleukin-6 in the Ascitic Fluid of Cirrhotic Patients with Spontaneous Bacterial Peritonitis.
- Published in:
- Clinical Infectious Diseases, 1993, v. 17, n. 2, p. 218
- By:
- Publication type:
- Article
A Nuclear Magnetic Resonance (NMR)- and Mass Spectrometry (MS)-Based Saturation Kinetics Model of a Bryophyllum pinnatum Decoction as a Treatment for Kidney Stones.
- Published in:
- International Journal of Molecular Sciences, 2024, v. 25, n. 10, p. 5280, doi. 10.3390/ijms25105280
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- Publication type:
- Article
Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO<sub>2</sub>(mpETSC)] and [Pt(mpETSC)Cl].
- Published in:
- Bioinorganic Chemistry & Applications, 2010, v. 2010, p. 1, doi. 10.1155/2010/149149
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- Publication type:
- Article