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- Title
The Biological Effect of Small Extracellular Vesicles on Colorectal Cancer Metastasis.
- Authors
Wang, Xiaoxing; Huang, Defa; Wu, Jiyang; Li, Zhengzhe; Yi, Xiaomei; Zhong, Tianyu
- Abstract
Colorectal cancer (CRC) is a malignancy that seriously threatens human health, and metastasis from CRC is a major cause of death and poor prognosis for patients. Studying the potential mechanisms of small extracellular vesicles (sEVs) in tumor development may provide new options for early and effective diagnosis and treatment of CRC metastasis. In this review, we systematically describe how sEVs mediate epithelial mesenchymal transition (EMT), reconfigure the tumor microenvironment (TME), modulate the immune system, and alter vascular permeability and angiogenesis to promote CRC metastasis. We also discuss the current difficulties in studying sEVs and propose new ideas.
- Subjects
EXTRACELLULAR vesicles; COLORECTAL cancer; METASTASIS; EPITHELIAL-mesenchymal transition; TUMOR microenvironment
- Publication
Cells (2073-4409), 2022, Vol 11, Issue 24, p4071
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells11244071