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- Title
Beta-Aminoisobutyric Acid Inhibits Hypothalamic Inflammation by Reversing Microglia Activation.
- Authors
Park, Byong Seo; Tu, Thai Hien; Lee, Hannah; Jeong, Da Yeon; Yang, Sunggu; Lee, Byung Ju; Kim, Jae Geun
- Abstract
Beta-aminoisobutyric acid (BAIBA), a natural thymine catabolite, is involved in the beneficial effects of exercise on metabolic disorders. In particular, it has been reported to reverse the inflammatory processes observed in the peripheral organs of animal models of obesity. Therefore, this study aimed to investigate whether BAIBA improves hypothalamic inflammation, which is also tightly coupled with the development of obesity. We observed that treatment with BAIBA effectively reversed palmitic acid-induced hypothalamic inflammation and microglial activation in vivo. Consistent with these findings, we confirmed that BAIBA reversed body weight gain and increased adiposity observed in mice fed with a high-fat diet. Collectively, the current findings evidence the beneficial impacts of BAIBA on the imbalance of energy metabolism linked to hypothalamic inflammation.
- Subjects
MICROGLIA; BODY weight; WEIGHT gain; HIGH-fat diet; WESTERN diet; METABOLIC disorders
- Publication
Cells (2073-4409), 2019, Vol 8, Issue 12, p1609
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells8121609