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- Title
Magnetic Resonance Parkinsonism Index Is Associated with REM Sleep Behavior Disorder in Parkinson's Disease.
- Authors
Urso, Daniele; Nigro, Salvatore; Tafuri, Benedetta; Gnoni, Valentina; Filardi, Marco; De Blasi, Roberto; Ray Chaudhuri, K.; Logroscino, Giancarlo
- Abstract
We investigated the association between the Magnetic Resonance Parkinsonism Index (MRPI) and REM sleep behavior disorder (RBD). We included 226 de novo PD patients (82 PD-RBD and 144 PD-noRBD) and 19 idiopathic RBD patients. Furthermore, 3T T1-weighted MR images were used for automated brainstem calculations. MRPI values were higher in the PD-RBD (p = 0.004) compared to PD-noRBD patients. Moreover, MRPI proved to be a significant predictor of REM Behavior Disorder Screening Questionnaire scores in PD (β = 0.195, p = 0.007) and iRBD patients (β = 0.582, p = 0.003). MRPI can be used as an imaging marker of RBD in patients with de novo PD and iRBD.
- Subjects
PARKINSON'S disease; BEHAVIOR disorders; RAPID eye movement sleep; MAGNETIC resonance; SLEEP disorders
- Publication
Brain Sciences (2076-3425), 2022, Vol 12, Issue 2, p202
- ISSN
2076-3425
- Publication type
Article
- DOI
10.3390/brainsci12020202