We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Co-administration of SR141716 with peptide YY<sub>3–36</sub> or oxyntomodulin has additive effects on food intake in mice.
- Authors
White, N. E.; Dhillo, W. S.; Liu, Y.-L.; Small, C. J.; Kennett, G. A.; Gardiner, J. V.; Ghatei, M. A.; Bloom, S. R.
- Abstract
Background: SR141716 has been shown to significantly inhibit food intake and reduce body weight by antagonizing CB1 receptors. The gut hormones peptide YY3–36 (PYY3–36) and oxyntomodulin (OXM) inhibit food intake through Y2 and Glucagon-Like-Peptide (GLP)-1 receptors respectively. Objective: To determine the effects of co-administration of SR141716 with either PYY3–36 or OXM in mice on food intake. Methods: Mice (n = 14 per group) were fasted for 16 h prior to study days and given two intraperitoneal injections: study 1, vehicle–saline, SR141716–saline, vehicle–PYY3–36 or SR141716–PYY3–36; study 2: vehicle–saline, SR141716–saline, vehicle–OXM or SR141716–OXM. Food was returned and measured following injections. Results: Co-administration of SR141716–PYY3–36 or SR141716–OXM showed greater inhibition in food intake when compared with administration of SR141716, PYY3–36 or OXM alone. Conclusion: Our data show that SR141716 in combination with PYY3–36 or OXM reduces food intake additively in mice.
- Subjects
DRUG administration; INGESTION; BODY weight; PEPTIDE hormones; GASTROINTESTINAL hormones; LABORATORY mice; ANTHROPOMETRY
- Publication
Diabetes, Obesity & Metabolism, 2008, Vol 10, Issue 2, p167
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/j.1463-1326.2007.00807.x