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- Title
Serum chloramphenicol concentrations in preruminant calves: a comparison of two formulations dosed orally.
- Authors
HUFFMAN, E. M.; CLARK, C. H.; OLSON, J. D.; BALL, L.
- Abstract
Serum concentrations of chloramphenicol were determined after oral doses (55 mg/kg body weight) were administered to 7-9 day old Holstein-Friesian calves. Chloramphenicol in an oral solution produced greater serum concentrations than did an equivalent dose of chloramphenicol in capsules ( P<0.005). A second dose of each formulation administered 12 h after the first dose elevated serum chloramphenicol concentrations significantly ( P<0.001). The average serum chloramphenicol concentration exceeded 5 μg/ml of serum 1 h after administration of the solution compared with 4 h for the capsules. Average serum chloramphenicol concentration was greater than 5 μg/ml for at least 12 h after the dose was administered for both formulations. Of the eight calves receiving repeat doses of chloramphenicol, seven (87.5%) developed diarrhea in 76 ± 8.6 h. Six of the eight calves (75%) died during or shortly after the period of chloramphenicol administration.
- Publication
Journal of Veterinary Pharmacology & Therapeutics, 1981, Vol 4, Issue 3, p225
- ISSN
0140-7783
- Publication type
Article
- DOI
10.1111/j.1365-2885.1981.tb00734.x