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- Title
Clinical trial: levofloxacin-based quadruple therapy was inferior to traditional quadruple therapy in the treatment of resistant Helicobacter pylori infection.
- Authors
YEE, Y. K.; CHEUNG, T. K.; CHU, K.‐M.; CHAN, C. K.; FUNG, J.; CHAN, P.; BUT, D.; HUNG, I.; CHAN, A. O. O.; YUEN, M. F.; HSU, A.; WONG, B. C. Y.
- Abstract
Background The efficacy of levofloxacin-based quadruple therapy in resistant Helicobacter pylori infection is not known. Aim To test the efficacy of levofloxacin-based quadruple therapy and traditional quadruple therapy in resistant H. pylori infection. Methods One hundred and two patients with resistant H. pylori infection were randomized to 1 week of either EBAL (esomeprazole 40 mg b.d., bismuth subcitrate 240 mg b.d., amoxicillin 1 g b.d. and levofloxacin 500 mg b.d.) or EBMT (esomeprazole 40 mg b.d., bismuth subcitrate 240 mg b.d., metronidazole 400 mg t.d.s. and tetracycline 500 mg q.d.s.). 13C-urea breath test was performed at week 12 to assess post-treatment H. pylori status. Results In intention-to-treat analysis H. pylori eradication was achieved in 37 of 51 (73%) subjects in EBAL and 45 of 51 (88%) subjects in EBMT groups, respectively ( P = 0.046). Per-protocol eradication rates of EBAL and EMBT groups were 78% and 94%, respectively ( P = 0.030). The intention-to-treat eradication rate was statistically lower for EBAL than EMBT (56% vs. 90%, P = 0.013) among those who had failed more than one course of eradication therapy. Previous levofloxacin triple therapy did not affect the efficacy of either protocol significantly. Conclusions Levofloxacin-based quadruple therapy was inferior to traditional quadruple therapy for resistant H. pylori infection.
- Subjects
HELICOBACTER pylori infections; ANTIPARASITIC agents; THERAPEUTICS; DRUG resistance in microorganisms; NATIVE element minerals
- Publication
Alimentary Pharmacology & Therapeutics, 2007, Vol 26, Issue 7, p1063
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2007.03452.x