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- Title
Early and frequent development of ocular hypertension in children with nephrotic syndrome.
- Authors
Kawaguchi, Emi; Ishikura, Kenji; Hamada, Riku; Nagaoka, Yoshinobu; Morikawa, Yoshihiko; Sakai, Tomoyuki; Hamasaki, Yuko; Hataya, Hiroshi; Noda, Eiichiro; Miura, Masaru; Ando, Takashi; Honda, Masataka
- Abstract
Background: Prednisolone, the first-line treatment for children with nephrotic syndrome, causes severe side effects. One of these side effects is ocular hypertension, which can result in severe and permanent visual disturbance. However, the exact prevalence, severity and timing of development of ocular hypertension have yet to be fully explored in this pediatric patient group. Methods: In this retrospective cohort study, children with nephrotic syndrome treated with prednisolone for their first episode were analyzed. Intraocular pressure was screened with an iCare® tonometer and confirmed with Goldmann applanation tonometry before the initiation of prednisolone treatment and at 1 and 4 weeks thereafter. Results: A total of 26 children with nephrotic syndrome were included in this study, of whom eight (30.8 %) required treatment with eye drops for ocular hypertension. The median time interval between the diagnosis of ocular hypertension and start of treatment was 9 (range 5-31) days. At relapse of nephrotic syndrome, all children who had undergone treatment for ocular hypertension in their first episode again required treatment for ocular hypertension. Conclusions: Routine ophthalmologic examination should be conducted from the early phase after the start of prednisolone treatment. In addition, children with episodes of ocular hypertension may be at greater risk of its reappearance with relapse of the nephrotic syndrome.
- Subjects
JAPAN; DIAGNOSIS of eye diseases; CHI-squared test; CONFIDENCE intervals; STATISTICAL correlation; EYE diseases; FISHER exact test; NEPHROTIC syndrome; PEDIATRICS; T-test (Statistics); TONOMETRY; RETROSPECTIVE studies; DATA analysis software; DESCRIPTIVE statistics; KAPLAN-Meier estimator; PREDNISOLONE; DISEASE complications
- Publication
Pediatric Nephrology, 2014, Vol 29, Issue 11, p2165
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-014-2848-x