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- Title
Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques and senescent keratinocytes.
- Authors
Qin, Jian-Zhong; Chaturvedi, Vijaya; Denning, Mitchell; Bacon, Patricia; Panella, Jeffry; Choubey, Divaker; Nickoloff, Brian
- Abstract
Presents a study which examined the regulation of apoptosis by p53 in ultaviolet (UV)-irradiated human epidermis, psoriatic plaques and senescent keratinocytes (KC). Induction and repair of UV-induced DNA thymine dimers in human skin; Dose effect of single UV-light exposure on p53 and p53 responsive protein and mRNA levels in human skin; Role of p53 in apoptotic response to UV-induced DNA damage.
- Subjects
APOPTOSIS; P53 antioncogene; KERATINOCYTES
- Publication
Oncogene, 2002, Vol 21, Issue 19, p2991
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1205404