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- Title
The EULAR Sjögren’s syndrome patient reported index as an independent determinant of health-related quality of life in primary Sjögren’s syndrome patients: in comparison with non-Sjögren’s sicca patients.
- Authors
Cho, Hyon Joung; Yoo, Jong Jin; Yun, Chan Young; Kang, Eun Ha; Lee, Hyo-Jung; Hyon, Joon Young; Song, Yeong Wook; Lee, Yun Jong
- Abstract
Objective. To investigate the significant determinants of health-related quality of life (HRQOL) and the association of the EULAR Sjögren’s syndrome patient reported index (ESSPRI) with clinical parameters including HRQOL in Korean patients with primary Sjögren’s syndrome (pSS) compared with non-SS sicca patients.Methods. We prospectively analysed 104 pSS and 42 non-SS sicca patients. Clinical data including Short Form 36 (SF-36) scores, self-assessments for symptoms and ESSPRI were cross-sectionally collected.Results. Although most self-assessments and HRQOL statuses were comparable, different association patterns between HRQOL and symptoms were observed in pSS and non-SS sicca patients. pSS patients with low HRQOL had significantly higher ESSPRI scores [P = 7.6 × 10−6 for physical component summary (PCS) subgroups and P = 0.0015 for mental component summary (MCS) subgroups] and ESSPRI scores showed a significant association with all SF-36 scales in pSS patients (all P ≤ 0.0020). Moreover, in multivariate linear regression analyses, ESSPRI (P = 0.035) and depression (P = 4.1 × 10−14) were significantly correlated with the PCS and the MCS, respectively. However, in the non-SS sicca group, xerostomia inventory (XI) scores were higher in the low PCS subgroup (P = 0.031) and this correlated with five SF-36 scales (all P ≤ 0.046). XI scores (P = 0.0039) and anxiety (P = 7.9 × 10−10) were the main determinants of the PCS and MCS, respectively.Conclusion. HRQOL levels were differentially associated with clinical facets in pSS and non-SS sicca patients, although the groups had similar clinical symptoms and HRQOL reduction. Because depression and ESSPRI are major determinants of HRQOL in Korean pSS patients, ESSPRI is suggested to be disease-specific for pSS.
- Subjects
KOREA; ACADEMIC medical centers; ANALYSIS of variance; BLOOD testing; CHI-squared test; COMPARATIVE studies; CONFIDENCE intervals; STATISTICAL correlation; FISHER exact test; HEALTH surveys; KERATOCONJUNCTIVITIS sicca; MULTIVARIATE analysis; QUALITY of life; REGRESSION analysis; RESEARCH funding; SELF-evaluation; SJOGREN'S syndrome; STATISTICS; T-test (Statistics); COMORBIDITY; DATA analysis; DATA analysis software; DESCRIPTIVE statistics
- Publication
Rheumatology, 2013, Vol 52, Issue 12, p2208
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/ket270