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- Title
Long‐term mucocutaneous adverse effects of imatinib in Indian chronic myeloid leukemia patients.
- Authors
Vinay, Keshavamurthy; Yanamandra, Uday; Dogra, Sunil; Handa, Sanjeev; Suri, Vikas; Kumari, Savita; Khadwal, Alka; Prakash, Gaurav; Lad, Deepesh; Varma, Subhash; Malhotra, Pankaj
- Abstract
Abstract: Background: Short‐term mucocutaneous adverse effects are well documented with imatinib. However, studies on long‐term adverse effects and in the ethnic population are lacking. Objective: To study the long‐term mucocutaneous adverse effects of imatinib and factors predicting these adverse effects. Methods: In this cross‐sectional study, consenting adult chronic myeloid leukemia patients on imatinib for more than 250 days were recruited. The details of imatinib treatment were retrieved from hematology clinic records. Results: Four hundred and thirty‐eight patients who were on imatinib for a mean duration of 1820 days were recruited. A mean number of 1.42 ± 0.98 cutaneous adverse effects were seen per patient. Melasma‐like pigmentation, periorbital edema, oral lichenoid reaction, cutaneous hypopigmentation, and vesicobullous eruptions were seen in 236 (53.9%), 81 (18.5%), 70 (16%), 42 (9.6%), and 12 (2.7%) patients, respectively. Drug‐induced cutaneous eruptions (9.1%) and cutaneous hypopigmentation (9.6%) were seen less frequently. Cutaneous hyperpigmentation was more likely seen in younger patients (<italic>P</italic> = 0.001) and females (<italic>P</italic> < 0.001). On multivariate analysis, female gender was a significant risk factor for developing cutaneous hyperpigmentation and periorbital edema. Conclusion: Cutaneous hyperpigmentation and periorbital edema are common long‐term adverse effects of imatinib in Indian patients. Female gender is a significant risk factor for the development of both these adverse effects.
- Subjects
DRUG side effects; IMATINIB; CHRONIC myeloid leukemia; CROSS-sectional method; HYPERPIGMENTATION; SKIN diseases
- Publication
International Journal of Dermatology, 2018, Vol 57, Issue 3, p332
- ISSN
0011-9059
- Publication type
Article
- DOI
10.1111/ijd.13852