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- Title
Postoperative Thyroid-Stimulating Hormone Levels Did Not Affect Recurrence after Thyroid Lobectomy in Patients with Papillary Thyroid Cancer.
- Authors
Myung-Chul Lee; Min Joo Kim; Hoon Sung Choi; Sun Wook Cho; Guk Haeng Lee; Young Joo Park; Do Joon Park
- Abstract
Background: Thyroid-stimulating hormone (TSH) suppression is recommended for patients who undergo thyroidectomy for differentiated thyroid cancer (DTC). However, the impact of TSH suppression on clinical outcomes in low-risk DTC remains uncertain. Therefore, we investigated the effects of postoperative TSH levels on recurrence in patients with low-risk DTC after thyroid lobectomy. Methods: Patients (n=1,528) who underwent thyroid lobectomy for papillary thyroid carcinoma between 2000 and 2012 were included in this study. According to the mean and dominant TSH values during the entire follow-up period or 5 years, patients were divided into four groups (<0.5, 0.5 to 1.9, 2.0 to 4.4, and =4.5 mIU/L). Recurrence-free survival was compared among the groups. Results: During the 5.6 years of follow-up, 21 patients (1.4%) experienced recurrence. Mean TSH levels were within the recommended low-normal range (0.5 to 1.9 mIU/L) during the total follow-up period or 5 years in 38.1% or 36.0% of patients. The mean and dominant TSH values did not affect recurrence-free survival. Adjustment for other risk factors did not alter the results. Conclusion: Serum TSH levels did not affect short-term recurrence in patients with low-risk DTC after thyroid lobectomy. TSH suppression should be conducted more selectively.
- Subjects
THYROID cancer; PAPILLARY carcinoma; THYROIDECTOMY; HORMONES; DISEASE risk factors
- Publication
Endocrinology & Metabolism, 2019, Vol 34, Issue 2, p150
- ISSN
2093-596X
- Publication type
Article
- DOI
10.3803/EnM.2019.34.2.150