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- Title
Rhabdomyolysis and Acute Kidney Injury Associated with Hypothyroidism and Statin Therapy.
- Authors
Pyoung Ahn; Hyun-Jun Min; Sang-Hyun Park; Byoung-Mu Lee; Myung-Jin Choi; Jong-Woo Yoon; Ja-Ryong Koo
- Abstract
Rhabdomyolysis is a syndrome involving the breakdown of skeletal muscle that causes myoglobin and other intracellular proteins to leak into the circulatory system, resulting in organ injury including acute kidney injury. We report a case of statin-induced rhabdomyolysis and acute kidney injury that developed in a 63-year-old woman with previously undiagnosed hypothyroidism. Untreated hypothyroidism may have caused her hypercholesterolemia requiring statin treatment, and it is postulated that statin-induced muscle injury was aggravated by hypothyroidism resulting in her full-blown rhabdomyolysis. Although this patient was successfully treated with continuous venovenous hemofiltration and L-thyroxin replacement, rhabdomyolysis with acute kidney injury is a potentially life-threatening disorder. Physicians must pay special attention to the possible presence of subclinical hypothyroidism when administering statins in patients with hypercholesterolemia.
- Subjects
RHABDOMYOLYSIS; SKELETAL muscle; MYOGLOBIN; HYPOTHYROIDISM; BLOOD filtration
- Publication
Endocrinology & Metabolism, 2013, Vol 28, Issue 4, p331
- ISSN
2093-596X
- Publication type
Case Study
- DOI
10.3803/EnM.2013.28.4.331