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- Title
Perioperative gabapentin as a component of multimodal analgesia for postoperative pain after total knee arthroplasty.
- Authors
Bayalagmaa Khuvtsagaan; Ganbold Lundeg
- Abstract
Background: Total knee arthroplasty (TKA) causes considerable postoperative pain. This study investigated the analgesic effects of gabapentin on postoperative pain in patients undergoing unilateral TKA in Mongolia. Methods: The study randomly assigned 95 patients with American Society of Anesthesiologists physical status class 1-3 scheduled for unilateral TKA into two groups. The treatment group (n = 49) was given gabapentin 600 mg 2 h preoperatively and gabapentin 300 mg in the evening for 3 days postoperatively. The control group (n = 46) was given identical looking placebo capsules. Pain using a visual analogue scale (VAS) and postoperative nausea and vomiting were assessed every hour postoperatively for 6 h and then every 3 h for the next 72 h. The total consumption of fentanyl in both groups was recorded at 24 and 48 h postoperatively. Results: The very low VAS scores in both groups did not differ significantly. Patients in the treatment group used less fentanyl on the second day (P = 0.001). The incidence of nausea and vomiting were similar in both groups, except for the low incidence of nausea in the treatment group in the first 6 h postoperatively. Conclusions: Perioperative gabapentin may be a component of a multimodal analgesia method because it reduced fentanyl consumption in patients who underwent TKA. However, the overall low VAS scores do not allow any firm conclusions.
- Subjects
GABAPENTIN; ANALGESIA; POSTOPERATIVE pain; TOTAL knee replacement; PLACEBOS
- Publication
Anesthesia & Pain Medicine, 2017, Vol 12, Issue 2, p169
- ISSN
1975-5171
- Publication type
Article
- DOI
10.17085/apm.2017.12.2.169