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- Title
Unbalanced expression of licensing DNA replication factors occurs in a subset of mantle cell lymphomas with genomic instability.
- Authors
Pinyol, Magda; Salaverria, Itziar; Bea, Silvia; Fernández, Verónica; Colomo, Lluís; Campo, Elías; Jares, Pedro
- Abstract
DNA licensing is a crucial process for chromosome replication control. Deregulation of the licensing factors Cdt1, Cdc6 and the licensing inhibitor geminin has been associated with DNA replication defects and chromosomal instability. We examined the expression of these factors, in mantle cell lymphoma (MCL) and non-neoplastic lymphoid samples, and analysed the potential role of their deregulation in genomic instability. Geminin, Cdt1 and Cdc6 were coordinately expressed in non-neoplastic tissues and most MCL in relationship to the proliferative activity of the cells. However, 6 (18%) tumours showed an unbalanced 'licensing signature' characterized by a higher expression of Cdt1 and Cdc6 than the negative regulator geminin. Tumours with this unbalanced signature and p53/p14
- Publication
International Journal of Cancer, 2006, Vol 119, Issue 12, p2768
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.22146