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- Title
Reversal of doxorubicin resistance in breast cancer cells by photochemical internalization.
- Authors
Lou, Pei-Jen; Lai, Ping-Shan; Shieh, Ming-Jium; MacRobert, Alexander J.; Berg, Kristian; Bown, Stephen G.
- Abstract
Multiple drug resistance (MDR) is a problem that seriously reduces the efficacy of many chemotherapy agents. One mechanism for MDR is increased acidification of endocytic vesicles and increased cytosol pH, so weak base chemotherapeutic agents, including doxorubicin, are trapped in endocytic vesicles and exhibit a drug resistant phenotype. Treatments that selectively reverse this accumulation may therefore reverse the MDR phenotype. Photochemical internalization (PCI) is a novel technology developed for site-specific enhancement of the therapeutic efficacy of macromolecules by selective photochemical rupture of endocytic vesicles and consequent release of endocytosed macromolecules into the cytosol. This study evaluates PCI for release of doxorubicin from endocytic vesicles in MDR cells. Two breast cancer cell lines, MCF-7 and MCF-7/ADR (the latter resistant to doxorubicin), were selected. They were found equally sensitive to photochemical treatment with the photosensitiser TPPS
- Publication
International Journal of Cancer, 2006, Vol 119, Issue 11, p2692
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.22098