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- Title
Dibenzo[ A,L]pyrene-induced genotoxic and carcinogenic responses are dramatically suppressed in aryl hydrocarbon receptor-deficient mice.
- Authors
Nakatsuru, Yoko; Wakabayashi, Keiji; Fujii-Kuriyama, Yoshiaki; Ishikawa, Takatoshi; Kusama, Kaoru; Ide, Fumio
- Abstract
Dibenzo[ a,l]pyrene (DB[ a,l]P), a notorious air pollutant, is the most powerful carcinogenic polycyclic aromatic hydrocarbon (PAH) ever tested. Although the carcinogenicity of PAH may be primarily mediated by the aryl hydrocarbon receptor (AhR), the in vivo role of AhR in skin carcinogenesis remains to be defined. In this context, we investigated the genotoxic and carcinogenic responses of the AhR-deficient mouse skin to DB[ a,l]P. A single painting resulted in a striking epidermal hyperplasia in AhR+/+ mice but not in AhR−/− mice. Bromodeoxyuridine-labeling index and accumulation of p53 protein in epidermal cells of AhR+/+ mice were 8- and 33-fold higher than those of AhR−/− mice, respectively.
- Publication
International Journal of Cancer, 2004, Vol 112, Issue 2, p179
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.20365