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- Title
Formulation and Evaluation of Colon Targeted Drug Delivery.
- Authors
Kumar, Amresh; Ali, Md. Zulphikar; Tiwari, Himani; Chandrul, Kaushal Kishor
- Abstract
The primary aim of this study is to create a targeted drug delivery system for Mesalamine, specifically aimed at the colon. Nine different formulations of Mesalamine tablets were developed using a combination of microbial degradation polymers such as Inulin, Locust bean gum, and Xanthan gum, along with MCC, PVPK30, magnesium stearate, and talc through the direct compression method. Various parameters including hardness, weight variation, drug content uniformity, friability, and in vitro drug release were evaluated for all the prepared tablets. FTIR studies indicated the absence of interactions between the drug and polymers. Among the formulations, F9 demonstrated the highest in vitro drug release of 96.25% over 12 hours, thus establishing it as the optimized formulation.
- Subjects
TARGETED drug delivery; DRUG delivery systems; XANTHAN gum; POLYMER degradation; LOCUST bean gum; COLON (Anatomy); MESALAMINE
- Publication
International Journal of Pharmacy & Life Sciences, 2024, Vol 15, Issue 2, p9
- ISSN
0976-7126
- Publication type
Article