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- Title
The Potential Roles of Probiotics, Resistant Starch, and Resistant Proteins in Ameliorating Inflammation during Aging (Inflammaging).
- Authors
Warman, Dwina Juliana; Jia, Huijuan; Kato, Hisanori
- Abstract
Aging is typically accompanied by biological and physiological changes that alter cellular functions. Two of the most predominant phenomena in aging include chronic low-grade inflammation (inflammaging) and changes in the gut microbiota composition (dysbiosis). Although a direct causal relationship has not been established, many studies have reported significant reductions in inflammation during aging through well-maintained gut health and microbial balance. Prebiotics and probiotics are known to support gut health and can be easily incorporated into the daily diet. Unfortunately, few studies specifically focus on their significance in reducing inflammation during aging. Therefore, this review summarizes the scientific evidence of the potential roles of probiotics and two types of prebiotics, resistant starch and resistant proteins, in later age. Studies have demonstrated that the oral consumption of bacteria that may contribute to anti-inflammatory response, such as Bifidobacterium spp., Akkermansia munichipilla, and Faecalis praunitzii, contributes significantly to the suppression of pro-inflammatory markers in elderly humans and aged animals. Colonic fermentation of resistant starch and proteins also demonstrates anti-inflammatory activity owing to the production of butyrate and an improvement in the gut microbiota composition. Collectively, probiotics, resistant starch, and resistant proteins have the potential to promote healthy aging.
- Subjects
INFLAMMATION prevention; BIFIDOBACTERIUM; PREBIOTICS; ACTIVE aging; COLON (Anatomy); ANTI-inflammatory agents; GUT microbiome; PROBIOTICS; DIETARY supplements; STARCH; DIETARY proteins; FERMENTATION; BUTYRIC acid
- Publication
Nutrients, 2022, Vol 14, Issue 4, p747
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14040747