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- Title
Effects of Fish Oil Supplementation on Oxidative Stress Biomarkers and Liver Damage in Hypercholesterolemic Rats.
- Authors
Lima Rocha, Joana Érica; Mendes Furtado, Mariely; Mello Neto, Renato Sampaio; da Silva Mendes, Ana Victória; Brito, Ana Karolinne da Silva; Sena de Almeida, José Otávio Carvalho; Rodrigues Queiroz, Emerson Iuri; de Sousa França, José Vinícius; Silva Primo, Maísa Guimarães; Cunha Sales, Ana Lina de Carvalho; Gomes Vasconcelos, Andreanne; Felix Cabral, Wanessa; Souza Kückelhaus, Selma Aparecida; de Souza de Almeida Leite, José Roberto; Fortes Lustosa, Ana Karina Marques; Lucarini, Massimo; Durazzo, Alessandra; Arcanjo, Daniel Dias Rufino; Martins, Maria do Carmo de Carvalho e
- Abstract
Metabolic syndrome, especially its component related to dyslipidemia, is related to the development of nonalcoholic fatty liver disease (NAFLD), which is a disease with a significant global prevalence. Supplementation with omega-3 polyunsaturated fatty acids emerged as a complementary therapeutic possibility for dyslipidemia, but its benefits are questioned. This paper aims at evaluating the effects of fish oil supplementation in rats with hypercholesterolemia induced by hypercholesterolemic diet (HD). The study design is based on an experimental model in which the animals were randomly divided into 3 groups: G1 (standard commercial feed + saline solution); G2 (hypercholesterolemic diet + saline solution) and G3 (hypercholesterolemic diet + fish oil) over a period of 16 weeks. Metabolic control parameters and oxidative stress biomarkers were evaluated according to standardized methodologies. The G3 group showed significantly lower values of plasma concentrations of TG, and hepatic myeloperoxidase as well as higher erythrocyte superoxide dismutase activity (p < 0.05). Regarding histopathological analysis, there was lipid accumulation in the liver of animals from group G2; meanwhile, hepatocytes reorganization and expressive reduction of lipid vacuoles and hepatic TG content was observed in group G3. This study demonstrated how fish oil supplementation reduced the plasma concentration and hepatic content of triglycerides, as well as liver tissue damage in histopathological analysis.
- Subjects
EXPERIMENTAL design; BIOMARKERS; ANIMAL experimentation; HYPERCHOLESTEREMIA; ANTIOXIDANTS; SUPEROXIDE dismutase; DIETARY supplements; OXIDATIVE stress; LIVER diseases; RATS; OXIDOREDUCTASES; STATISTICAL sampling; FISH oils
- Publication
Nutrients, 2022, Vol 14, Issue 3, p426
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14030426