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- Title
Body Mass Index, Weight Loss, and Mortality Risk in Advanced-Stage Non-Small Cell Lung Cancer Patients: A Focus on EGFR Mutation.
- Authors
Chen, Yu-Mu; Lai, Chien-Hao; Lin, Chiung-Yu; Tsai, Yi-Hsuan; Chang, Ya-Chun; Chen, Hung-Chen; Tseng, Chia-Cheng; Chang, Huang-Chih; Huang, Kuo-Tung; Chen, Yung-Che; Fang, Wen-Feng; Wang, Chin-Chou; Chao, Tung-Ying; Lin, Meng-Chih
- Abstract
Body mass index (BMI) influences the prognosis of patients with non-small cell lung cancer (NSCLC), including both early-stage and late-stage NSCLC patients that are undergoing chemotherapies. However, earlier research on the relationship between BMI and survival in patients taking epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) yielded contradictory results. These publications either had a limited number of patients or were getting TKIs in various lines of therapy, which might explain why the outcomes were contradictory. As a result, we undertook retrospective study to examine the effect of BMI on survival outcomes in patients with advanced EGFR mutant NSCLC receiving first-line EGFR-TKIs. We also compared the findings to those with wild-type EGFR. Between November 2010 and March 2014, 513 patients with advanced NSCLC were enrolled in the study. According to the adjusted BMI cut-off point for Asia, 35 out of 513 (6.8%) patients were underweight (BMI < 18.5 kg/m2), whereas 197 (38.4%) were overweight (BMI > 24 kg/m2). Overweight patients with wild-type EGFR exhibited longer progression-free survival (4.6 vs. 2.1 months, p = 0.003) and overall survival (OS) (8.9 vs. 4.3 months, p = 0.003) than underweight patients. Overweight patients with EGFR mutations had a longer OS than normal-weight patients (23.0 vs. 20.2 months, p = 0.025). Bodyweight reduction was related to a shorter OS in both the mutant EGFR patients (17.1 vs. 30.5 months, p < 0.001) and the wild-type EGFR patients (7.8 vs. 18.7 months, p < 0.001). In conclusion, advanced stages NSCLC patients with a lower BMI and early weight loss had a worse outcome that was independent of EGFR mutation status.
- Subjects
LUNG cancer prognosis; MORTALITY risk factors; LUNG cancer; EVALUATION of medical care; SURVIVAL; OBESITY; GENETIC mutation; EPIDERMAL growth factor receptors; RETROSPECTIVE studies; PROTEIN-tyrosine kinase inhibitors; CANCER patients; LEANNESS; WEIGHT loss; BODY mass index
- Publication
Nutrients, 2021, Vol 13, Issue 11, p3761
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13113761