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- Title
Dietary Intake of Magnesium or Calcium and Chemotherapy-Induced Peripheral Neuropathy in Colorectal Cancer Patients.
- Authors
Wesselink, Evertine; Winkels, Renate M.; van Baar, Harm; Geijsen, Anne J. M. R.; van Zutphen, Moniek; van Halteren, Henk K.; Hansson, Bibi M. E.; Radema, Sandra A.; de Wilt, Johannes H. W.; Kampman, Ellen; Kok, Dieuwertje E. G.
- Abstract
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and severe side-effect in colorectal cancer (CRC) patients. This study assessed the association between habitual dietary intake of magnesium or calcium and prevalence and severity of chronic CIPN in CRC patients receiving adjuvant chemotherapy. For this prospective cohort study, 196 CRC patients were considered. Magnesium and calcium intake was determined using a food frequency questionnaire at diagnosis, during and after chemotherapy. Chronic CIPN was assessed 12 months after diagnosis using the quality of life questionnaire CIPN20. Prevalence ratios were calculated to assess the association between magnesium or calcium intake and the prevalence of CIPN. Multivariable linear regression analysis was used to assess the association between magnesium or calcium intake and severity of CIPN. CIPN was reported by 160 (82%) patients. Magnesium intake during chemotherapy was statistically significantly associated with lower prevalence of CIPN (prevalence ratio (PR) 0.53, 95% confidence interval (CI) 0.32, 0.92). Furthermore, higher dietary intake of magnesium during (β −1.08, 95% CI −1.95, −0.22) and after chemotherapy (β −0.93, 95% CI −1.81, −0.06) was associated with less severe CIPN. No associations were found for calcium intake and the prevalence and severity of CIPN. To conclude, we observed an association between higher dietary magnesium intake and lower prevalence and severity of CIPN in CRC patients.
- Subjects
THERAPEUTIC use of magnesium; DIETARY calcium; COLON tumors; COMBINED modality therapy; DIETARY supplements; LONGITUDINAL method; PERIPHERAL neuropathy; QUESTIONNAIRES; RECTUM tumors; MULTIPLE regression analysis; SEVERITY of illness index; THERAPEUTICS
- Publication
Nutrients, 2018, Vol 10, Issue 4, p398
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu10040398