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- Title
Critical Biological Pathways for Chronic Psychosocial Stress and Research Opportunities to Advance the Consideration of Stress in Chemical Risk Assessment.
- Authors
Mcewen, Bruce S.; Tucker, Pamela
- Abstract
Emerging evidence suggests that psychosocial stress and toxicants may interact to modify health risks. Stress- toxicant interactions could be important in chemical risk assessment, but these interactions are poorly understood and additional research is necessary to advance their application. Environmental health research can increase knowledge of these interactions by exploring hypotheses on allostatic load, which measures the cumulative impacts of stress across multiple physiological pathways, using knowledge about physiological pathways for stress related health effects, and evidence of common target pathways for both stress and toxicants. In this article, critical physiological pathways for stress related health effects are discussed, with specific attention to allostatic load and stress-toxicant interactions, concluding with research suggestions forpotentialapplications of such research in chemical risk assessment.
- Subjects
HEALTH &; psychology; CENTRAL nervous system; EMPLOYMENT; ENVIRONMENTAL health; PSYCHOPHYSIOLOGY; RISK assessment; PSYCHOLOGICAL stress; TOXINS; UNITED States. Environmental Protection Agency; NATIONAL Academy of Sciences (U.S.); HEALTH equity
- Publication
American Journal of Public Health, 2011, Vol 101, Issue S1, pS131
- ISSN
0090-0036
- Publication type
Article
- DOI
10.2105/AJPH.2011.300270