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- Title
Effect of Perindopril on Large Artery Stiffness and Aortic Root Diameter in Patients With Marfan Syndrome.
- Authors
Ahimastos, Anna A.; Aggarwal, Anuradha; D'Orsa, Kellie M.; Formosa, Melissa F.; White, Anthony J.; Savarirayan, Ravi; Dart, Anthony M.; Kingwell, Bronwyn A.
- Abstract
This article reports on the findings of a clinical trial looking at the effect of perindopril on large artery stiffness and aortic root diameter in patients with Marfan Syndrome (MFS). Marfan is a connective tissue disorder caused by genetic mutation in FBN1 with is the gene that encodes fibrillin 1. Β-blockers are the therapy for the disease in 2007 but they may not address the underlying causes. The study found that perindopril reduced aortic stiffness and the aortic root diameter in patients who were taking standard Β blocker therapy. The authors call for larger trials to assess the value of angiotensin II blockers in the treatment of the disease.
- Subjects
CLINICAL trial registries; MARFAN syndrome treatment; ANGIOTENSIN-receptor blockers; CONNECTIVE tissue diseases; ADRENERGIC beta blockers; GENETIC disorders; ARTERIAL disease treatment; GENETIC polymorphisms; HEALTH outcome assessment; THERAPEUTICS
- Publication
JAMA: Journal of the American Medical Association, 2007, Vol 298, Issue 13, p1539
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.298.13.1539