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- Title
Association of Polymorphisms in the CRP Gene With Circulating C-Reactive Protein Levels and Cardiovascular Events.
- Authors
Lange, Leslie A.; Carlson, Christopher S.; Hindorff, Lucia A.; Lange, Ethan M.; Walston, Jeremy; Durda, J. Peter; Cushman, Mary; Bis, Joshua C.; Zeng, Donglin; Lin, Danyu; Kuller, Lewis H.; Nickerson, Deborah A.; Psaty, Bruce M.; Tracy, Russell P.; Reiner, Alexander P.
- Abstract
The article focuses on a cardiovascular health study in the United States which looked at 3,941 white people, and 700 black people over the age of 65 with no history of stroke or heart disease in order to assess whether polymorphisms in the C-reactive inflammation protein (CRP) gene are associated with plasma CRP, carotid intima-media thickness (CIMT) and cardiovascular disease (CVD) events in older adults. Differences which were seen between the black and white subjects are discussed. Researchers found that genetic variation in the CRP gene is associated with plasma CRP levels and CVD risk in older adults.
- Subjects
UNITED States; HEART disease research; C-reactive protein; INFLAMMATORY mediators; HEALTH risk assessment of older people; DISEASE risk factors; PHYSIOLOGY
- Publication
JAMA: Journal of the American Medical Association, 2006, Vol 296, Issue 22, p2703
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.296.22.2703