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- Title
Non-gastrin secretogogue in ulcerogenic tumors of the pancreas.
- Authors
Chey, William Y.; Chang, T.-M.; Park, Hyoung Jin; Lee, Kae Yol; Escoffery, Robert; Chen, Yuan Fang; Shah, Achok N.; Hamilton, David; You, Chul H.; Menguy, Rene; Chey, W Y; Park, H J; Lee, K Y; Escoffery, R; Chen, Y F; Shah, A N; Hamilton, D; You, C H; Manguy, R
- Abstract
In 18 patients with hypersecretion of acid, severe ulcer diathesis, and pancreatic islet cell tumor or hyperplasia, 14 had hypergastrinemia and 4 had normal plasma gastrin concentration. The neoplasms contained several gut peptides beside gastrin. The immunoreactive gastrin in the tumor extracts measured less than 7 ng/g, less than the amount previously reported. The extracts of each patient's tumor also contained a secretogogue other than gastrin that stimulated gastric acid secretion in rats. In addition, the plasma extracts of 2 patients also contained a secretogogue that stimulated acid secretion. After surgical resection of a recurrent metastatic tumor in 1 patient, basal acid secretion decreased from 13.9 to less than 1 meq/h, and the bioactivity of the plasma disappeared. These observations suggest the existence of a secretogogue that appears to be a protein in the pancreatic tumors of some patients with severe ulcer diathesis and hypersecretion.
- Subjects
PANCREATIC tumors; PEPTIC ulcer; PATIENTS; HYPERPLASIA; ADENOMA; MULTIPLE endocrine neoplasia; ANIMAL experimentation; COMPARATIVE studies; FLUORESCENT antibody technique; GASTRIC juice; IMMUNOENZYME technique; RESEARCH methodology; MEDICAL cooperation; RADIOIMMUNOASSAY; RATS; RESEARCH; TISSUE extracts; EVALUATION research; ISLET cell tumor; DISEASE complications
- Publication
Annals of Internal Medicine, 1984, Vol 101, Issue 1, p7
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-101-1-7