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- Title
Endothelial microparticles: Sophisticated vesicles modulating vascular function.
- Authors
Curtis, Anne M; Edelberg, Jay; Jonas, Rebecca; Rogers, Wade T; Moore, Jonni S; Syed, Wajihuddin; Mohler, Emile R
- Abstract
Endothelial microparticles (EMPs) belong to a family of extracellular vesicles that are dynamic, mobile, biological effectors capable of mediating vascular physiology and function. The release of EMPs can impart autocrine and paracrine effects on target cells through surface interaction, cellular fusion, and, possibly, the delivery of intra-vesicular cargo. A greater understanding of the formation, composition, and function of EMPs will broaden our understanding of endothelial communication and may expose new pathways amenable for therapeutic manipulation.
- Subjects
ENDOTHELIAL cells; VESICLES (Cytology); PARACRINE mechanisms; THERAPEUTICS; CELL fusion
- Publication
Vascular Medicine, 2013, Vol 18, Issue 4, p204
- ISSN
1358-863X
- Publication type
Article
- DOI
10.1177/1358863X13499773