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- Title
The del/del genotype of the nuclear factor-kappaB -94ATTG polymorphism and its relation to aggressive periodontitis.
- Authors
Schulz S; Hierse L; Altermann W; Klapproth J; Zimmermann U; Reichert Y; Gläser C; Kluttig A; Stein JM; Schaller H; Reichert S
- Abstract
Schulz S, Hierse L, Altermann W, Klapproth J, Zimmermann U, Reichert Y, Gläser C, Kluttig A, Stein JM, Schaller H-G, Reichert S. The del/del genotype of the nuclear factor-[kappa]B -94ATTG polymorphism and its relation to aggressive periodontitis. J Periodont Res 2010; 45: 396-403. © 2010 John Wiley & Sons A/S Background and Objective: Periodontitis is influenced by specific host-dependent immune responses. Periodontopathogens induce innate immune responses, amongst others, via toll-like receptor 2 (TLR2), resulting in activation of the nuclear transcription factor nuclear factor-[kappa]B (NF-[kappa]B). The aim of this case-control study was to evaluate links between genetic variants of these genes and chronic/aggressive periodontitis in a multivariate model. Material and Methods: A total of 141 patients with periodontitis (63 with chronic periodontitis and 78 with aggressive periodontitis) and 81 controls without periodontitis were included in the study. Polymorphisms in TLR2 (Arg677Trp, Arg753Gln) and in NF-[kappa]B (-94ins/delATTG) were determined by restriction fragment length polymorphism and fragment length analyses, respectively. Subgingival bacterial colonization was evaluated using a PCR/DNA probe test (micro-Ident(R)). Results: Although there was no association of the TLR2 polymorphism Arg753Gln with periodontitis, heterozygous carriers (Arg/Gln) were at a higher risk for colonization with bacteria of the 'red complex' (corrected p-value = 0.042). The del/del genotype of the NF-[kappa]B polymorphism was associated with aggressive periodontitis considering age, gender, smoking and approximal plaque index as potential confounders (odds ratio = 2.81, p = 0.035, 95% confidence interval: 1.08-7.33). del/del carriers had a higher risk for subgingival colonization with Aggregatibacter actinomycetemcomitans (odds ratio = 2.36, p = 0.030, 95% confidence interval: 1.09-5.1; adjusted for age, gender, smoking and pocket depthbacteria). Conclusions: The del/del genotype of NF-[kappa]B was shown to be associated with the occurrence of aggressive periodontitis.
- Publication
Journal of Periodontal Research, 2010, Vol 45, Issue 3, p396
- ISSN
0022-3484
- Publication type
Journal Article
- DOI
10.1111/j.1600-0765.2009.01251.x