We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Survival of early posthematopoietic stem cell transplantation relapse of myeloid malignancies.
- Authors
de Jong, Greta; Janssen, Jeroen J. W. M.; Biemond, Bart J.; Zeerleder, Sacha S.; Ossenkoppele, Gert J.; Visser, Otto; Nur, Erfan; Meijer, Ellen; Hazenberg, Mette D.
- Abstract
Objective: Relapse of AML after allogeneic hematopoietic stem cell transplantation (HSCT) has a poor prognosis, and standard of care therapy is lacking. Early (<6 months) relapse is associated with dismal outcome, while the majority of relapses occur early after transplantation. A more precise indication which patients could benefit from reinduction therapy is warranted. Methods: We retrospectively analyzed outcomes of 83 patients with postallogeneic HSCT relapse. Patients were divided based on intention to treat (curative vs supportive care). Results: Of the 50 patients treated with curative intent, 44% reached complete remission (CR) upon reinduction chemotherapy, and of these patients, 50% survived. Two survivors reached CR after immunotherapy (donor lymphocyte infusion (DLI), without reinduction chemotherapy). Sixty‐nine percent of the survivors had received high‐intensity cytarabine treatment, followed by immunologic consolidation. Relapse <3 months after transplantation was predictive for adverse survival (P = .004), but relapse <6 months was not. In fact, >50% of the survivors had a relapse <6 months. Conclusion: We confirmed the dismal prognosis of postallogeneic HSCT relapse. Importantly, our data demonstrate that patients fit enough to receive high‐dose chemotherapy, even when relapse occurred <6 months, had the best chance to obtain durable remissions, in particular when immunologic consolidation was performed after reaching CR.
- Subjects
STEM cell transplantation; HEMATOPOIETIC stem cell transplantation
- Publication
European Journal of Haematology, 2019, Vol 103, Issue 5, p491
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/ejh.13315