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- Title
Can chlorogenic acid reduce oxidative stress and in an experimental spinal cord injury?
- Authors
Bal, Ercan; Hanalıoğlu, Şahin; Apaydın, Aydın Sinan; Bal, Ceylan; Şenat, Almila; Gümüşkaya, Berrak; Bahadır, Burak; Türkoğlu, Ömer Faruk
- Abstract
BACKGROUND: We aimed to investigate antioxidant and neuroprotective properties of chlorogenic acid in spinal cord injury (SCI). METHODS: Twenty-one rats were divided into three groups. Laminectomy was performed in group L (n=7), spinal cord trauma was induced in group T (n=7), and spinal cord trauma was induced and chlorogenic acid treatment was started in group C (n=7). Blood samples were collected to analyze baseline values and the 12th h, 1st day, 3rd day, and 5th day catalase, native thiol (NT), total thiol (TT), disulfide (SS), SS/TT, SS/NT, and NT/TT levels. Functional analysis with Basso-Beattie and Bresnahan scores was performed at the same time points. Total antioxidant status (TAS), total oxidative stress, oxidative stress index, and cyclooxygenase-2 (Cox-2) were examined in the spinal cord of rats euthanized on day 7; results were statistically analyzed. RESULTS: On day 7, catalase levels in Group C were significantly higher than baseline levels, whereas those in Group T were significantly lower than baseline levels; Group L showed no significant difference (p=0.008). SS values on day 7 were lower in Group T than in Groups C and L. Group C showed the lowest decrease in NT/TT level after trauma. On day 7, SS/TT level was high in Group T but stable in Groups C and L (p=0.04). Histopathological examination revealed significantly lower Cox-2 and TAS levels in Group C than in Group T (p=0.003, p=0.017, respectively). CONCLUSION: In this study, SCI was primarily examined through thiol-SS balance, and it was demonstrated by experimental models that chlorogenic acid has antioxidant and neuroprotective effects in SCI.
- Subjects
SULFUR compounds analysis; ANTIOXIDANT analysis; SPINAL cord injuries; ANIMAL experimentation; OXIDATIVE stress; RATS; CATALASE; OXIDOREDUCTASES; CARBOCYCLIC acids
- Publication
Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi, 2022, Vol 28, Issue 2, p125
- ISSN
1306-696X
- Publication type
Article
- DOI
10.14744/tjtes.2020.89499