We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A radiomic approach for adaptive radiotherapy in non-small cell lung cancer patients.
- Authors
Ramella, Sara; Fiore, Michele; Greco, Carlo; Cordelli, Ermanno; Sicilia, Rosa; Merone, Mario; Molfese, Elisabetta; Miele, Marianna; Cornacchione, Patrizia; Ippolito, Edy; Iannello, Giulio; D’Angelillo, Rolando Maria; Soda, Paolo
- Abstract
The primary goal of precision medicine is to minimize side effects and optimize efficacy of treatments. Recent advances in medical imaging technology allow the use of more advanced image analysis methods beyond simple measurements of tumor size or radiotracer uptake metrics. The extraction of quantitative features from medical images to characterize tumor pathology or heterogeneity is an interesting process to investigate, in order to provide information that may be useful to guide the therapies and predict survival. This paper discusses the rationale supporting the concept of radiomics and the feasibility of its application to Non-Small Cell Lung Cancer in the field of radiation oncology research. We studied 91 stage III patients treated with concurrent chemoradiation and adaptive approach in case of tumor reduction during treatment. We considered 12 statistics features and 230 textural features extracted from the CT images. In our study, we used an ensemble learning method to classify patients’ data into either the adaptive or non-adaptive group during chemoradiation on the basis of the starting CT simulation. Our data supports the hypothesis that a specific signature can be identified (AUC 0.82). In our experience, a radiomic signature mixing semantic and image-based features has shown promising results for personalized adaptive radiotherapy in non-small cell lung cancer.
- Subjects
NON-small-cell lung carcinoma; CANCER radiotherapy; CANCER diagnosis; COMPUTER simulation; RADIOACTIVE tracers
- Publication
PLoS ONE, 2018, Vol 13, Issue 11, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0207455