We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effects of Coenzyme Q<sub>10</sub> on LDL Oxidation In vitro.
- Authors
Ahmadvand, Hassan; Mabuchi, Hiroshi; Nohara, Atsushi; Kobayahi, Junji; Kawashiri, Masa-aki
- Abstract
Coenzyme Q10, a lipid soluble benzoquinone, has excellent antioxidant and membrane stabilizing properties in the cardiac tissue. The present study investigated the effects of coenzyme Q10 on in vitro LDL oxidation quantitavely. The formation of conjugated dienes, malondialdehyde (MDA) and electrophoretic mobility were monitored as markers of the oxidation of LDL, respectively. Coenzyme Q10 showed a decrease the formation of conjugated dienes and MDA, respectively, against oxidation in vitro. Coenzyme Q10 also reduced electrophoretic mobility of the oxidized human LDL. Thus, results showed that the coenzyme Q10 exhibits strong antioxidant activity in CuSO4-mediated oxidation of LDL (P<0.05) in vitro. The inhibitory effects of the coenzyme Q10 on LDL oxidation were dose-dependent at concentrations ranging from 20 nM to 300 nM. Moreover, the effects of coenzyme Q10 on LDL oxidation were compared with vitamin E and vitamin C. This study showed that coenzyme Q10 is a potent antioxidant to protect LDL against oxidation in vitro and may be a good alternative to reduce the risk of atherosclerosis and coronary heart disease and other free radical associated health problems.
- Subjects
UBIQUINONES; OXIDATION; IN vitro studies; LOW density lipoproteins; BENZOQUINONES; ELECTROPHORESIS; ANTIOXIDANTS; CARDIOVASCULAR disease prevention
- Publication
Acta Medica Iranica, 2013, Vol 51, Issue 1, p12
- ISSN
0044-6025
- Publication type
Article