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- Title
Near Normalisation of Lumbar Spine Bone Density in Young Women with Osteopenia Recovered from Adolescent Onset Anorexia Nervosa: A Longitudinal Study.
- Authors
Bass, Shona L.; Saxon, Leanne; Corral, Anne-Marie; Rodda, Christine P.; Strauss, Boyd J. G.; Reidpath, Daniel; Clarke, Caroline
- Abstract
To investigate the effect of the progression of adolescent onset anorexia nervosa (AN) on bone parameters we followed two cohorts (Disease cohort and recovered cohort) of adolescents for a total of 5.2 years. In the 'Disease' cohort (n = 18), lumbar spine bone density (BMD) was reduced by 0.6 SD after 0.8 years of disease and was reduced a further 1.0 SD after a total 2.5 years of disease (p <0.001). At the third lumbar vertebra there was bone loss (-3.7%, ? <0.05) resulting in reduced volumetric BMD (-5.1%, ? <0.08). In the 'recovered' cohort, lumbar spine BMD was reduced by 1.9 SD after 1.7 years of disease, and increased by 1.5 SD after 2.7 years of recovery (p <0.001). At the third lumbar vertebra there was an increase in bone mass (20.5%, ? <0.001) and bone volume (14.1%, ? <0.001), resulting in increased volumetric BMD (6.3%, ? <0.08). Normalisation of lumbar spine BMD may be achieved in patients with adolescent onset AN when the successful recovery of body weight is combined with the return of regular menses.
- Publication
Journal of Pediatric Endocrinology & Metabolism, 2005, Vol 18, Issue 9, p897
- ISSN
0334-018X
- Publication type
Article
- DOI
10.1515/jpem.2005.18.9.897