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- Title
Exploring the Solid-Phase Synthesis of Sulfotyrosine Peptides.
- Authors
Vale, Nuno; Carvalho Veloso, Rita; Gomes, Paula
- Abstract
Tyrosine sulfation is a common post-translational modification operative in many biological processes, including hemostasis and intracellular trafficking. However, the precise structural and functional role of sulfotyrosine residues is not fully understood, so there is a demand for further detailed studies on the role of tyrosine sulfation in biochemical processes. Unfortunately, studies on the biological roles of tyrosine sulfation are hampered by difficulties in gaining access to large quantities of high-purity and homogeneous sulfoproteins and sulfopeptides. This, however, may be addressed by appropriate solid-phase peptide synthesis strategies, and these constitute the core subject of this review. An overview of efficient approaches to the synthesis of sulfopeptides and their associated pros and cons is presented.
- Subjects
TYROSINE; AMINO acids; ORGANIC compounds; ORGANIC synthesis; ORGANIC chemistry
- Publication
European Journal of Organic Chemistry, 2015, Vol 2015, Issue 34, p7413
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201500715