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- Title
Theoretical basis for and improvement of Daugirdas' second generation formula for single-pool Kt/V.
- Authors
Sternby, Jan; Daugirdas, John T.
- Abstract
<bold>Purpose: </bold>An empirically-derived equation to estimate hemodialysis treatment variable-volume single-pool Kt/V, where Kt/V = -In(R-GFAC × t) + (4-3.5 × R) × UFV/W, was published in 1993 (1) and quickly became a standard tool for the estimation of dialysis dose. We aim to find a theoretical basis for this equation.<bold>Methods: </bold>A mathematical derivation is used to find the connection between Kt/V and modeled urea concentrations.<bold>Results: </bold>There is a theoretical basis for the empirical structure of the estimating equation, but the estimation of the effect of ultrafiltration on Kt/V can be improved. Finally, we show that the accuracy of the formula may be suboptimal for some extreme dialysis schedules and propose a new equation that is more robust across atypical dialysis prescriptions.<bold>Conclusions: </bold>The currently used Kt/V estimating equation has a sound theoretical basis and an improved version is proposed that can maintain accuracy with a broader range of fluid removal.
- Publication
International Journal of Artificial Organs, 2015, Vol 38, Issue 12, p632
- ISSN
0391-3988
- Publication type
journal article
- DOI
10.5301/ijao.5000456