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- Title
Poor Performance of Rapid Molecular Tests to Define Eligibility for the Shortcourse Multidrug-resistant Tuberculosis Regimen.
- Authors
Guglielmetti, Lorenzo; Sougakoff, Wladimir; Maitre, Thomas; Brossier, Florence; Jarlier, Vincent; Robert, Jérôme; Veziris, Nicolas; Aubry, Alexandra
- Abstract
The World Health Organization recommends shortcourse regimen (SCR) to treat multidrug resistant tuberculosis for patients with strains susceptible by line-probe assays (LPAs) to second-line drugs. Our retrospective study shows LPAs have suboptimal specificity in predicting eligibility for SCR; a quarter of eligible patients would receive inadequate therapy with SCR.
- Subjects
FRANCE; BACTERIOPHAGE typing; CONFIDENCE intervals; MEDICAL records; MOLECULAR diagnosis; MULTIDRUG resistance; RETROSPECTIVE studies; DATA analysis software; DESCRIPTIVE statistics
- Publication
Clinical Infectious Diseases, 2019, Vol 68, Issue 8, p1410
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciy808