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- Title
Increased prevalence of herpes viruses in high grade CIN and carcinoma of the cervix: the potential for synergistic effect.
- Authors
Baldauf, J. -J.; Dreyfus, M.; Monlun, E.; Ritter, J.; Obert, G.
- Abstract
Objective: To assess the prevalence of human papillomavirus (HIV) type 16 and 18, herpes simplex virus (HSV) and human cytomegalovirus (HCMV) in cervical biopsies in order to evaluate their relationship in cervical intraepithelial neoplasia (CIN) and cancer. Setting: Colposcopy clinic; Service de (Gyne é cologic-Obst é trique I. H ô pital de Hautepierre. H ô pitaux Universitaires de Strasbourg and Laboratoire Commun ULP/Synth é labo et U74 INSERM. Institut de Virologie de Ia Facult é de M é decine de Strasbourg, France. Subjects: Forty-two women with low grade and high grade CIN, twenty women with cervical squamous cancer and twenty-two women with normal cervix assessed by cytological, colposcopical and histological analysis. Methods: Viral DNA was detected by PCR technique in colposcopically directed biopsies. Results: The prevalence of HPV16 and/or HPV18 with HSV and/or HCMV was significantly higher in cancers (25%) or high grade CIN (29%) than in normal cervices (0%). On the contrary, when only HPV DNA was found, there was no significant difference between cancers (30%), high grade CIN (29%) and normal cervices (9%). Conclusions: The results support the hypothesis of a role of herpes viruses (HSV and [HCMV) as cofactors in cervical carcinogenesis.
- Subjects
FRANCE; CANCER; HERPESVIRUS diseases; VIRUS diseases; PAPILLOMAVIRUSES; COLPOSCOPY
- Publication
Journal of the European Academy of Dermatology & Venereology, 1995, Vol 4, Issue 1, p104
- ISSN
0926-9959
- Publication type
Article
- DOI
10.1016/0926-9959(94)00084-D