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- Title
Tristetraprolin down-regulates IL-17 through mRNA destabilization
- Authors
Lee, Hyun Hee; Yoon, Nal Ae; Vo, Mai-Tram; Kim, Chae Won; Woo, Je Moon; Cha, Hee Jeong; Cho, Young Woo; Lee, Byung Ju; Cho, Wha Ja; Park, Jeong Woo
- Abstract
Abstract: An excess of interleukin 17 (IL-17) may contribute to chronic inflammatory disorders, but mechanisms that regulate IL-17 in immune cells are unclear. Here we report that tristetraprolin (TTP) inhibits IL-17 production in human T cell lines. Overexpression of TTP decreased the expression of IL-17. Conversely, TTP inhibition by siRNA increased IL-17 production. IL-17 mRNA contains eight AREs within its 3′UTR. TTP bound directly to the IL-17 mRNA 3′UTR at a location between the fourth and seventh AREs and enhanced decay of IL-17 transcripts. These results suggest that TTP could control IL-17-mediated inflammation.
- Subjects
ZINC-finger proteins; MESSENGER RNA; INTERLEUKINS; T cells; GENETIC transcription; IMMUNOLOGY of inflammation; CELL culture
- Publication
FEBS Letters, 2012, Vol 586, Issue 1, p41
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2011.11.021